For regenerative and preventive purposes, it is worth to use Biofiton Healthy Vessels Phytotablets include medicinal plants, the effect of which is aimed at:

  1. NORMAL PRESSURE. Biologically active substances of Hawthorn Flowers, Birch Leaves and Horsetail Aerial Parts improve heart work and regulate blood pressure.
  2. NORMAL BLOOD FLOW. Hawthorn Flowers, Melilot Aerial Parts, Horse Chestnut Seeds, Horsetail Aerial Parts and Buckwheat Flowers have mild action and favorable effect on blood circulation.
  3. NORMAL CHOLESTEROL LEVEL. Active substances of Alder Buckthorn Bark and Peppermint Leaves prevent fatty deposits on vascular walls and maintain normal blood cholesterol level.
  4. STRENGTHENING AND CLEARANCE. Common Periwinkle and Melilot Aerial Parts, Dog Rose Fruits and Cowberry Leaves clean vessels from various deposits, normalizing their elasticity and flexibility.
  5. NORMAL METABOLISM. Hawthorn Flowers, Horse Chestnut Seeds, Dog Rose Fruits and Buckwheat Flowers activate metabolic processes, providing delivery of nutrients to all body cells, thus normalizing the blood flow.

 

Atherosclerosis (Latin atheromatosis, atherosclerosis) (colloquial name is “atherosclerosis”) – a chronic disease consisting of degenerative changes in the inner and middle membrane of the arteries, mainly in the aorta, coronary arteries, cerebral arteries and limb arteries.

RISK FACTORS

• Impossible to modify:
– age
– male gender
– genetic disorders

• Potentially controllable:
– hyperlipidemia
hypertension
– smoking tobacco
diabetes

• Risk factors that are less important, uncertain or difficult to quantify:
– obesity
– lack of physical activity
– stress (personality type A)
– estrogen deficiency (after menopause)
– a large amount of carbohydrates in the diet
– high level of lipoprotein (a) [Lp (a)]
– eating saturated and unsaturated (trans) hardened fats
– Chlamydia pneumoniae infection.

Pathogenesis
The hypothesis of development of atherosclerosis treats it as a chronic response of vascular wall of inflammatory nature, initiated by endothelial damage. The following processes are important in it:

• Chronic endothelial damage – the result of which is its dysfunction, leading to increased permeability, leukocyte adhesion and disruption
• balance in the production and release of signaling particles affecting the functional state of the vessel walls, as well as favorable thrombosis.
• The entry of modified (oxidized, glycated) lipoproteins, mainly LDL containing high cholesterol, into the vascular wall.
• Modification of lipoproteins within the change due to their oxidation.
• Adherence of blood monocytes (and other leukocytes) to the endothelium followed by their migration to the inner membrane and transformation into macrophages and foam cells.
• Adhesion of platelets.
• Release of active agents by activated platelets, macrophages or vascular cells of factors that cause migration of smooth muscle cells from the median membrane to the intima.
• Proliferation of smooth muscle cells in the inner membrane and production of extracellular matrix, which leads to the deposition of collagen and proteoglycans.
• Increased lipid accumulation in both cells (macrophages and smooth muscle cells) as well as extracellular

NATURAL DEVELOPMENT OF DISEASE
Atherosclerosis involves the islet-like accumulation of cholesterol (and its esters) and other lipids in the internal membrane. In the first stage, endothelial cells accumulate excessive amounts of cholesterol and lipids, which are moved under the inner membrane of the arteries (the so-called fatty streaks). These types of changes can already be observed in children. Subendothelial lipid-cholesterol masses cause macrophage accumulation, fibroblast proliferation and smooth muscle cells of the medial layer of the artery as well as small blood vessels coming from vessels that nourish the artery wall (Latin vasa vasorum). It is assumed that foam cells forming atherosclerotic plaques accumulated lipids originating from blood plasma lipoproteins by the so-called scavenging pathways that have previously been damaged by reactive oxygen species.
The next stage is calcification of these foci (so-called dystrophic calcification, Latin calcificatio dystrophica), leading to atherosclerosis of the arteries, and the appearance of endothelial defects above the atherosclerotic focus. Endothelium loss is the reason for the local decrease in the concentration of prostacyclin – the factor preventing the accumulation of platelets. As a result of this process, at the sites exposed from the intima, ulcerous ulcerations (ulcerous ulcerations) occur, which become areas of peripheral platelet aggregation and thrombosis (thrombosis parietalis).
Local consequences
The atherosclerotic process leads to a reduction in the lumen of the arteries and a decrease in their elasticity. For unknown reasons (it can not be ruled out that due to the lack of additional bacterial superinfection) in some people in places of outbreaks cholesterol do not undergo ulceration and calcification, and the growing atherosclerotic plaque is made of fibrous tissue and numerous capillaries. These foci – called “atherosclerotic plaques” are covered with live endothelium and rarely become the site of thrombosis growth, but quite often they are the site of hematoma formation, thus closing the lumen of the artery. In turn, calcified plaques are an area of ​​thrombosis and may burst, which also leads to the occlusion of the artery.
Location of atherosclerotic lesions
Atherosclerosis appears almost exclusively in the arteries of the large circulatory system, especially in those places where there is high blood pressure (aorta and arteries that depart directly from it) and blood flow is not laminar (especially in places of arterial branching).
Naming issues
The name atherosclerosis as a disease process (Latin atheromatosis) applies to all its stages. It comes from gr. “Α̉θήρη” (athere) about the original meaning of “mush from flour”, which later took on the meaning of “porridge”. This name refers to the “porous” appearance of the defect in the artery wall. The term “atherosclerosis” is called advanced forms of atherosclerosis in which sclerosis of the artery wall occurred due to an atherosclerotic process. It is a concept narrower than “arteriosclerosis” (Latin arteriosclerosis, Latin artery – artery + Latin sclerosis – sclerosis), which can also be caused by other causes than atherosclerosis, e.g. senile arteriosclerosis (Latin arteriosclerosis senilis) , inflammatory arteriosclerosis (Latin arteriosclerosis postinflammatoria), arterioles sclerosis (Latin arteriolosclerosis), Monckeberg’s sclerosis (Latin calcificatio mediae).
The consequences of atherosclerosis
Atherosclerosis of the cerebral arteries causes cerebral ischemia and mental changes, facilitates vessel ruptures and strokes (especially with coexisting hypertension). Coronary atherosclerosis is one of the causes of coronary disease, atherosclerosis of the aorta can lead to the formation of aneurysm.

PREVENTION
In treatment, a proper diet, an active lifestyle, rational rest and appropriate supplementation are of great importance.

For regenerative and preventive purposes, it is worth to use Biofiton Healthy Vessels Phytotablets include medicinal plants, the effect of which is aimed at:

  1. NORMAL PRESSURE. Biologically active substances of Hawthorn Flowers, Birch Leaves and Horsetail Aerial Parts improve heart work and regulate blood pressure.
  2. NORMAL BLOOD FLOW. Hawthorn Flowers, Melilot Aerial Parts, Horse Chestnut Seeds, Horsetail Aerial Parts and Buckwheat Flowers have mild action and favorable effect on blood circulation.
  3. NORMAL CHOLESTEROL LEVEL. Active substances of Alder Buckthorn Bark and Peppermint Leaves prevent fatty deposits on vascular walls and maintain normal blood cholesterol level.
  4. STRENGTHENING AND CLEARANCE. Common Periwinkle and Melilot Aerial Parts, Dog Rose Fruits and Cowberry Leaves clean vessels from various deposits, normalizing their elasticity and flexibility.
  5. NORMAL METABOLISM. Hawthorn Flowers, Horse Chestnut Seeds, Dog Rose Fruits and Buckwheat Flowers activate metabolic processes, providing delivery of nutrients to all body cells, thus normalizing the blood flow.